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      HSP70  Mouse mAb
      
                    EM1042
                    
      
                        
      
                            
      
                                規(guī)格：
                                價格：
                            
      
                                                        
      
                                50μL
                                ￥1280.00
                            
      
                                                        
      
                                100μL
                                ￥1980.00
                            
      
                                                    
      
                    
      
                    
                
      
            
      
        
      

                
      
            
      
                
      Overview
                    
      
                
      
                    
      
                        
      
                            
      
                                
      
                                    
      
                                        Product name:
                                        HSP70  Mouse mAb
                                    
      
                                                                            
      
                                            Reactivity:
                                            Human, Rat, Mouse
                                        
      
                                                                                
      
                                            Alternative Names:
                                            Heat shock 70 kDa protein 1/2, heat shock 70kDa protein 1A, HSP70, HSP70 1, HSP70 1/HSP70 2, HSP70 1A, HSP70.1/HSP70.2, HSP70I, HSP72, HSPA1, HSPA1A, HSPA1B
                                        
      
                                                                                
      
                                           Source:
                                           Mouse
                                           
                                        
      
                                                                                
      
                                           Dilutions:
                                           WB 1:1,000-2,000 IF 1:100-200? IHC 1:200-500
                                           
                                        
      
                                                                                
      
                                           Immunogen:
                                           Synthetic Peptide
                                           
                                        
      
                                                                                
      
                                           Storage:
                                           PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid?repeated?freeze-thaw?cycles.
                                           
                                        
      
                                                                                
      
                                           Clonality:
                                           Monoclonal
                                           
                                        
      
                                                                                
      
                                           Isotype:
                                           IgG1
                                           
                                        
      
                                                                                
      
                                           Concentration:
                                           1mg/mL
                                           
                                        
      
                                                                                
      
                                           Observed Band:
                                           70kDa
                                           
                                        
      
                                                                                
      
                                           GeneID:
                                           3303
                                           
                                        
      
                                                                                
      
                                           Human Swiss-Prot No:
                                           P0DMV8
                                           
                                        
      
                                                                                
      
                                           Cellular localization:
                                           Cytoplasm
                                           
                                        
      
                                                                                
      
                                           Background:
                                           The 70 kilodalton heat shock proteins (Hsp70s) are a family of ubiquitously expressed heat shock proteins. Proteins with similar structure exist in virtually all living organisms. The Hsp70s are an important part of the cell's machinery for protein folding, and help to protect cells from stress. Hsp70 is usually in an ATP bound state. Hsp70 by itself is characterized by a very weak ATPase activity, such that spontaneous hydrolysis will not occur for many minutes. As newly synthesized proteins emerge from the ribosomes, the substrate binding domain of Hsp70 recognizes sequences of hydrophobic amino acid residues, and interacts with them. This spontaneous interaction is reversible, and in the ATP bound state Hsp70 may relatively freely bind and release peptides. However, the presence of a peptide in the binding domain stimulates the ATPase activity of Hsp70, increasing its normally slow rate of ATP hydrolysis.
                                           
                                        
      
                                                                        
      
                            
      
                                                    
      
                    
      
                
      
            
      
                        
                    
      
    
      
    




      
    
      
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